The Efficacy of Fractional CO2 Laser in the Treatment of Genitourinary Syndrome of Menopause: A Large Prospective Observational Study

Background: Genitourinary syndrome of menopause (GSM) majorly caused by the physiological decline in estrogen, affects up to 90% menopausal women. Hormonal therapy seems be an effective treatment, often not executable for contraindication or patient’s low compliance local systemic medical therapy. Fractional CO2 laser is emerging and choice women affected vulvo-vaginal atrophy (VVA), promoting collagen regeneration improving blood flow vaginal mucosa elasticity tissues. Methods: Ninety-two Patients (VVA) were considered present prospective observational study. All treated with Lumenis AcuPulse a fractionated sequential mode pulse. requested complete questionnaires regarding Female Sexual Functional Index (FSFI), Distress Scale (FSDS) severity Most Bothersome Symptoms (MBS) at baseline (T0) three-month following three-treatment-sessions (T1). Results: Data indicated significant improvement MBS (vaginal itching (p < 0.0001), post-coital bleeding 0.002), dryness dyspareunia 0.0001) dysuria higher Vaginal Health Score (VHIS) (4.1 ± 1.21; 95% CI = 3.84–4.35) reduces pH (–0.53 0.24; 0.48–0.58) after treatment. A significantly FSFI Total score FSDS have been demonstrated. Conclusions: improves health as well signs symptoms associated GSM, while elevating quality life sexual functionality among postmenopausal symptomatic